Healthcare is Broken
Costs skyrocket but healthspan and lifespan are decreasing
Rising Healthcare Costs
U.S. healthcare spending reached $4.5 trillion in 2024, representing 17.3% of GDP - more than any other developed nation. The average American now spends over $13,000 annually on healthcare...
U.S. healthcare spending reached $4.5 trillion in 2024, representing 17.3% of GDP - more than any other developed nation. The average American now spends over $13,000 annually on healthcare, with costs rising 4-6% per year. Despite this massive investment, Americans face mounting medical debt, with 100 million people struggling to pay medical bills. The system prioritizes reactive treatment over prevention, leading to skyrocketing costs for managing preventable chronic diseases.
Decreasing Life Expectancy
For the first time in a century, U.S. life expectancy has declined for three consecutive years, dropping to 76.4 years - the lowest since 1996. This places America behind 40+ other countries...
For the first time in a century, U.S. life expectancy has declined for three consecutive years, dropping to 76.4 years - the lowest since 1996. This places America behind 40+ other countries, including Cuba and Estonia. The causes are largely preventable: chronic inflammation-related diseases, metabolic disorders, and cardiovascular disease account for most premature deaths. Meanwhile, countries spending less on healthcare but investing more in prevention see their life expectancy continue to rise.
Reduced Healthspan
While total lifespan decreases, healthspan - the years lived in good health - is declining even faster. Americans now spend an average of 12-14 years living with chronic disease and disability before death...
While total lifespan decreases, healthspan - the years lived in good health - is declining even faster. Americans now spend an average of 12-14 years living with chronic disease and disability before death. Nearly 60% of adults have at least one chronic condition, and 42% have two or more. Inflammatory diseases like diabetes, heart disease, arthritis, and Alzheimer's rob people of quality life decades before death. The current healthcare system waits until disease is advanced rather than catching and preventing inflammation-driven disease early.
Affordable, Proactive Inflammation Monitoring
Revolutionary point-of-care diagnostics delivering lab-grade inflammatory biomarker analysis from a single drop of blood in under 10 minutes. Fast, affordable, and convenient testing from your home - no clinic visits, no wait times, just instant health insights.
The Impact
High-frequency, affordable cytokine monitoring transforms healthcare from reactive to proactive by enabling early detection and personalized baselines.
Inflammation as an Early Detector
Making cytokines rapid and affordable at point-of-care (previously only available in research labs at high cost)
Early Detection
Cytokines appear hours before clinical symptoms across infections, radiation exposure, toxin exposure, and disease progression
Broad Applicability
The same 5-marker panel provides insights across 50+ conditions—sepsis, COVID-19, autoimmune disease, cancer, cardiovascular disease, aging
Threat-Agnostic
Cytokine signatures indicate something is wrong even when you don't know what the threat is yet (unlike pathogen-specific tests)
High-Frequency Monitoring
High frequency testing is mandatory for personalized and proactive healthcare of any kind, and for this to work it needs to be easy to do
Makes Data More Powerful
Cytokine signatures change rapidly over hours to days, requiring frequent measurement to be clinically useful. Existing solutions cannot do this
Establishes Personal Baselines
Regular testing reveals your unique inflammatory patterns, making it easier to detect meaningful changes that signal health issues specific to you
Increases Analysis Accuracy
Multiple data points over time provide context that single snapshots cannot, reducing false positives and revealing true health trends
Why Inflammation
Understanding your body's inflammatory response provides critical insights into your health status, disease risk, and treatment effectiveness across multiple conditions.
IL-6 is a key inflammatory mediator that plays crucial roles in immune response, metabolism, and tissue repair processes.
Key Applications:
- Depression and mood disorder monitoring
- Cardiovascular disease risk assessment
- Autoimmune disease activity tracking
- Post-exercise recovery monitoring
- Aging and inflammaging indicators
- Cancer-related inflammation detection
TNF-α is a potent pro-inflammatory cytokine central to immune system activation and chronic inflammatory conditions.
Key Applications:
- Rheumatoid arthritis and autoimmune monitoring
- IBD and gastrointestinal inflammation
- Metabolic syndrome and insulin resistance
- Sepsis and acute infection detection
- Anti-TNF therapy effectiveness monitoring
- Neuroinflammation assessment
IL-1β is a master regulator of inflammation, driving fever, acute phase responses, and tissue damage in various diseases.
Key Applications:
- Acute infection and fever monitoring
- Gout and crystal arthropathy detection
- Alzheimer's and neurodegeneration tracking
- Post-surgical inflammation assessment
- Autoinflammatory syndrome monitoring
- Wound healing and tissue repair
IFN-γ is a critical immune activator that enhances pathogen clearance and regulates adaptive immune responses.
Key Applications:
- Viral and intracellular infection monitoring
- Tuberculosis and mycobacterial detection
- Cancer immunotherapy response tracking
- Autoimmune disease activity assessment
- Vaccine response evaluation
- Immunodeficiency screening
IL-10 is a powerful anti-inflammatory cytokine that regulates immune responses and promotes tissue healing.
Key Applications:
- Treatment response monitoring
- Immune system balance assessment
- Post-infection recovery tracking
- Chronic fatigue and burnout evaluation
- Allergic reaction monitoring
- Pregnancy and maternal health
Revolutionary Point-of-Care Diagnostics
Proactive Dx delivers lab-grade inflammatory biomarker analysis from a single drop of blood in under 10 minutes. Our silicon photonic biosensor platform transforms how we monitor, prevent, diagnose, and manage inflammation-driven conditions.
Rapid
Results
Get lab-comparable results from a finger-prick blood sample in under 10 minutes, eliminating the need for clinic visits and long turnaround times.
Comprehensive Profiling
Simultaneous quantification of multiple inflammatory biomarkers including IL-1β, IL-6, TNF-α, IFN-γ, and IL-10 from a single test.
Point-of-Care Access
Use anywhere with our portable device - at home, in clinics, or at the office. No training required with our simple 4-step process.
AI-Driven
Insights
Cloud connectivity with intelligent analysis, longitudinal tracking, and personalized health recommendations powered by advanced AI.
Affordable Healthcare
Low-cost instrument ($300) and cartridges ($3-20) make continuous health monitoring accessible to everyone.
Connected Experience
Seamless mobile app integration, EMR compatibility, and telemedicine support for comprehensive healthcare management.
Transforming Healthcare
Across Every Setting
From clinical applications to wellness monitoring and cutting-edge research, our platform serves diverse healthcare needs worldwide. Real-time inflammatory biomarker data enables precise diagnosis, treatment optimization, and breakthrough scientific discoveries.
About Proactive Dx
We're revolutionizing healthcare by democratizing access to critical inflammatory biomarker testing. With chronic inflammatory diseases causing over 50% of global deaths, our mission is to put powerful diagnostic tools directly in the hands of patients and providers.
Team
Reuven Duer, Ph.D.
Founder, CTO
Lifelong medical device engineer who led medical engineering teams and founded Proactive Dx with breakthrough silicon photonic biosensor technology.
LinkedIn Profile →
Dylan Brownstein
Cofounder, CEO
Led U.S. hardware & AI investments at Karcher, consulted for Google, Reddit, and YMCA. Previous founder at Prosper and Light Theory.
LinkedIn Profile →
Aren Giske, M.D.
Chief Operating Officer
Medical director with extensive experience in occupational & environmental medicine. Board member at Kadlec Medical and proven operations leader.
LinkedIn Profile →Our Technology
Our proprietary silicon photonic biosensor platform uses advanced optical detection to measure cytokines - the language of our immune system. This breakthrough technology delivers laboratory-quality results with the convenience of at-home testing, enabling real-time health monitoring and personalized care.
Clinical Applications
From optimizing depression treatment through inflammatory profiling to monitoring cardiovascular health, autoimmune diseases, and aging biomarkers, our platform serves diverse healthcare needs. We're particularly focused on treatment-resistant depression, where inflammatory markers can guide therapy selection and improve patient outcomes.
Ready to Transform Healthcare?
Join thousands of early adopters who are revolutionizing their health monitoring with cutting-edge inflammation diagnostics.
Contact: dylan@pro-dx.com